A Powerful Function-Preserving Therapy
Patients with prostate disease are searching for alternatives to active surveillance and radical therapies to maintain their quality of life.1 Expand their treatment options with the NanoKnife System, a powerful function-preserving therapy that can meet their needs.2
The NanoKnife System harnesses the nonthermal power of irreversible electroporation to effectively destroy diseased tissue. The unique mechanism of action reimagines localized therapy, improving precision, increasing preservation and expanding versatility to ensure treatments can be tailored with confidence.
Reliable Ablation
Electrical pulses destroy all living cells within the treatment area with no skip lesions.3,4
Generous Margins
Increased margin expansion without negatively impacting the rates of erectile function and incontinence in men.5,6
Less Collateral Damage
Ability to ablate across the urethra, nerves, and urinary sphincters to ensure treatment of lesions near vital structures while preserving a patient’s quality of life.7,8
Unmatched Versatility
Can treat all segments of the prostate, allowing physicians to build expertise in a single technology to optimize outcomes for patients.9,10
Easy Integration
Treatment typically takes one hour and seamlessly integrates into your practice utilizing existing imaging and biopsy skills.10.11
Conserve Future Options
Procedures can be repeated if necessary and do not interfere with more standard treatments such as surgery or radiotherapy.12
More About IRE for Soft Tissue
Precision Empowered.
- Sculpt and control ablation zone through multiple electrode configurations.8
- IRE effectively destroys targeted tissue giving you precise treatment margins resulting in confident treatment coverage.13,14
- Sharp demarcation of IRE-ablated zone is well-visualized using real-time ultrasound.15
Preservation Redefined.
- Spares vital structures by retaining the functional anatomy of the targeted tissue.9,15
- Preserves the extra-cellular matrix, facilitating post-ablation, histological and functional tissue regeneration.9,15
Versatility Perfected.
- IRE treatment can be confidently delivered in all segments of an organ.8
- Electrodes can be confidently placed near vital structures, maximizing your ability to personalize treatment to your patient’s anatomy.13,14
1. Murray TBJ. The Pathogenesis of Prostate Cancer. In: Bott SRJ, Ng KL, eds. Prostate Cancer. Brisbane (AU): Exon Publications; May 27, 2021.
2. Scheltema MJ, Geboers B, Blazevski A, et al. Median 5-year outcomes of primary focal irreversible electroporation for localised prostate cancer. BJU Int. 2023;131 Suppl 4:6-13. doi:10.1111/bju.15946
3. van den Bos, W et al. “Histopathological Outcomes after Irreversible Electroporation for Prostate Cancer: Results of an Ablate and Resect Study.” The Journal of urology vol. 196,2 (2016): 552-9. doi:10.1016/j.juro.2016.02.2977
4. Fainberg, Jonathan et al. “Targeted Ablation Using Ultrasound-Guided Irreversible Electroporation of Index Tumors (TARGET Study): Prospective Development Study Evaluating Safety, Patient-Reported Outcomes, and Oncologic Efficacy.” Urology practice, 101097UPJ0000000000000666. 17 Jul. 2024, doi:10.1097/UPJ.0000000000000666
5. Blazevski A, Scheltema MJ, Yuen B, et al. Oncological and quality-of-life outcomes following focal irreversible electroporation as primary treatment for localised prostate cancer: A biopsy-monitored prospective cohort. European Urology Oncology. 2020;3(3):283-290. doi:10.1016/j.euo.2019.04.008
6. de la Rosette, Jean et al. “A Multicenter, Randomized, Single-blind, 2-Arm Intervention Study Evaluating the Adverse Events and Quality of Life After Irreversible Electroporation for the Ablation of Localized Low-intermediate Risk Prostate Cancer.” The Journal of urology vol. 209,2 (2023): 347-353. doi:10.1097/JU.0000000000003051
7. Onik, Gary, et al. “Irreversible electroporation: Implications for prostate ablation.” Technology in Cancer Research & Treatment , vol. 6, no. 4, Aug. 2007, pp. 295–300, https://doi.org/10.1177/153303460700600405.
8. Blazevski, Alexandar, et al. “Focal ablation of apical prostate cancer lesions with irreversible electroporation (IRE).” World Journal of Urology, vol. 39, no. 4, 2 June 2020, pp. 1107–1114, https://doi.org/10.1007/s00345-020-03275-z.
9. Scheltema, Matthijs J et al. “Impact on genitourinary function and quality of life following focal irreversible electroporation of different prostate segments.” Diagnostic and interventional radiology (Ankara, Turkey) vol. 24,5 (2018): 268-275. doi:10.5152/dir.2018.17374
10. Pivotal study of the NanoKnife system for the ablation of prostate tissue. ClinicalTrials.gov website. Accessed June 28, 2024. https://clinicaltrials.gov/study/NCT04972097
11. Cussenot O and Stricker P. Irreversible Electroporation for Patients with Localised Prostate Cancer: Expert Opinion on this Versatile Therapeutic Approach. EMJ Urol. 2021;9(1):56-62.
12. Van Riel LAMJG, Geboers B, Kabaktepe E, et al. Outcomes of salvage radical prostatectomy after initial irreversible electroporation treatment for recurrent prostate cancer. BJU Int. 2022;130(5):611-618. doi:10.1111/bju.15759
13. Lee EW, Thai S, Kee ST. Irreversible electroporation: a novel image-guided cancer therapy. Gut Liver. (2010);4(SUPPL. 1):99–104. doi: 10.5009/gnl.2010.4.S1.S99
14. Guidance for Selection of NanoKnife Probe Array Configuration and Ablation parameters for the Treatment of Stage III Pancreatic Cancer.
15. Lee EW, Chen C, Prieto VE, Dry SM, Loh CT, Kee ST., Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation. Radiology 255:426–433. (2010). doi: 10.1148/radiol.10090337.